Letty Morris is a New York hoofer who hot-foots it out of the Big Town on a cross-country bus to get away from the unwanted attentions of "Legs" Caffey, a racketeer smitten with her charms. Learning of her plan to vamoose, Legs gets on the bus so his lady won't get away. Paul Porter, a jailbird, has broken out of the big house and is hiding at the bus stop, among passengers' luggage. The bus carrying Letty and Legs makes a stopover, and Porter hops on. Soon, a prisoner of love, Porter is making goo-goo eyes at Letty, much to the consternation of Legs, who threatens to turn him in. But Letty is gaga over Porter, and realizing the dame he desires is in love with another guy, Legs permits Porter to disappear. Detective Daly, hot on the trail of Porter, catches the bus, waiting for Letty's eluded beau to try to reunite with her, so he can make the pinch and get Porter back into the hoosegow. During an overnight stop, Porter absconds with the bus, and he and Letty take it on the lam. The buffaloed bulls take after the fleeing lovebirds in a thrilling car chase.