As Mormon settlers head to the promised land at the San Juan river in Utah, they hire horse traders Travis Blue and Sandy as wagon masters. They have to forge a trail across unknown territory and face many hardships along the way. They quickly come across some stranded travelers, a medicine show run by Dr. A. Locksley Hall which includes the attractive Denver. Along the way however, they are also joined by Shiloh Clegg and his murderous clan of robbers and thieves. An encounter with the Navajo leads to an invitation to their camp but after one of the Clegg boys gets a whipping for attacking one of the Navajo women, Uncle Shiloh plans his revenge. It's left to Sandy and Travis to protect the travelers and get them to their destination.